Dual immunotherapy and fever
On 29.04. I had my second infusion with the dual therapy opdivo and yervoy and I started getting fever up to 38.7 degrees. It all lasted for a whole week where I was taking paracetamol and ibuprofen, now I still get chills but the fever sometimes disappears on its own and it's up to 37.4 degrees. My liver enzymes were high last week, I may need to check them this week. On my first infusion on 01.04. I got fever on the second week and it went up to 40 degrees with elevated liver enzymes, which resulted in my prescription of dexamethasone for a week, which helped a lot.
My question is- for the people who got through this whole cycle, or even 1 or 2 infusions'- did you get fever? How long it lasted? My oncologist said if the liver enzymes don't drop, they will carry on with monotherapy. I decided to make consultation with the top melanoma specialist in my country because it's a relapse I'm treating and I'm afraid I'm not giving my best chance to kill the little monsters if I switch to monotherapy and he said that it's very uncommon for people to get high fever while on therapy. Colitis, hepatitis (which i have 2 grade), pancreatitis, pneumonitis were much more common. I'm wondering what is going on here? And apart from the fever and mild hepatitis I don't have any other side effects. Then he referred to gastroenterologist who specializes with autoimmune hepatitis.
And please spare the :ask your oncology team advice. I already did, just having 2 opposite opinions. My main oncologist said it's absolutely expected to raise temperature while on therapy.