u/Visible_Iron_5612

Fibroblast bioelectric signaling drives hair growth

https://www.sciencedirect.com/science/article/abs/pii/S0092867425008578

A 2025 Cell paper found that fibroblast bioelectric signaling drives hair growth. Specifically, KCNJ2-driven hyperpolarization in dermal fibroblasts promoted hair growth, while depolarization delayed the growth phase. They even reported rescue effects in aging and androgenetic alopecia models. Tiny voltage gremlins in the scalp, apparently.

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u/Visible_Iron_5612 — 4 hours ago

The Collective Intelligence of Cells During Morphogenesis with Michael Levin - Incredible Minds

https://youtu.be/D2xPFlOYLoQ?si=8CH3rGU97LHa-qFd

This presentation by Michael Levin, titled "The Collective Intelligence of Cells During Morphogenesis," explores the concept of multiscale agency and intelligence within biological systems, suggesting that our understanding of mind needs to expand beyond the central nervous system to include all living matter.

Key Takeaways and Concepts:

• Intelligence as Collective Problem-Solving: Levin argues that all intelligence is fundamentally collective, emerging from the competencies of simpler subunits. These subunits, such as individual cells, act as agents solving problems within diverse "problem spaces" (2:20-2:38).

• Bioelectricity as Cognitive Glue: The video highlights that developmental bioelectricity functions as an ancient "cognitive glue" that pre-dates the evolution of brains and muscles. This bioelectric signaling allows cells to communicate and make collective decisions about body shape, essentially navigating anatomical morphospace (33:42-34:08, 59:19-59:39).

• Rewritable Biological Software: Levin details how his lab has developed tools to read and write these bioelectric patterns, allowing them to induce tissue to form new structures (like eyes in non-eye tissue) or repair traumatic injuries (1:04:15-1:05:08, 1:07:34-1:08:14).

• Synthetic Bioengineering (Xenobots): The talk showcases the creation of Xenobots—novel, synthetic organisms derived from frog skin cells. These organisms demonstrate extraordinary plasticity, capable of navigating their environment and even engaging in kinematic replication (building copies of themselves from loose cells) without traditional genetic programming (1:43:24-1:47:56).

• The Cognitive Light Cone: Levin introduces the "cognitive light cone" as a framework for measuring the capacity of any agent, biological or synthetic, to pursue goal states, allowing for a more inclusive ethical view of diverse types of beings (1:31:01-1:32:00).

Impact on Medicine and Ethics:

The research has profound implications for regenerative medicine, particularly in addressing birth defects, cancer, and injury repair, by harnessing the inherent intelligence of the body's tissues rather than just micromanaging genetics (1:18:03-1:18:10, 1:43:05-1:43:22). Levin concludes by calling for a more expansive compassion for beings that exist outside our traditional understanding of biology.

u/Visible_Iron_5612 — 1 day ago
🔥 Hot ▲ 616 r/MichaelLevinBiology+1 crossposts

Insects, including bees, may possess forms of subjective experience showing emotional states, attention, and cognitive bias which challenge the view that consciousness requires a large brain, according to a 2025 review in Philosophical Transactions of the Royal Society.

u/Cosmyka — 10 days ago