What would make you put down Spy x Family or, in the case of an ending, make you forever refuse to touch it again? (spoilers)
I'll start this by saying that Spy x Family is the best anime and best manga I've ever partaken of. And I've been through a bunch.
The only reason I am waiting on buying all of the Spy x Family anime and all of the manga and filling a large shelf with them is precisely because I want to see how the story ends.
The thing I'd most likely put down the series over is if the story ends with Loid and Yor real-marrying someone other than each other. Or, the finale ends with Loid and/or Yor lying dead on the floor in a pool of their own blood. Or, they survive, but sever all contact with each other, and the Forger family dies. I've also seen spy/assassin anime where the protagonist is so concerned about his own hide that he sacrifices or kills everybody near him to assure survival.
I sure hope it doesn't come to that -- and, honestly, there have been enough such stories that I think Endo is simply too smart and resourceful to go that route.
What about you? Is there anything that make you abandon the story forever? If so, what and why?