Basically the final nail in the coffin
Hey y’all, long time lurker, and thought it was time to share my story.
Been TTC for going on three years, and decided I should probably get checked. Initial SA showed zero sperm, so my urologist put me on Chlomid for six months and redid labs. It had no effect and my latest SA still had zero sperm found.
He said it would probably be nothing but he ordered a DNA test to check my genetics for a root cause. Got the results back and my Y chromosomes are basically nonexistent, despite being a developmentally normal male. As such, the chromosomes that control fertility and sperm production are deleted or malformed, so my chances of naturally conceiving is close to zero.
We are moving towards doing a Micro-TESE, but that’s difficult because with the genetic problem, there’s less than a 5% chance they find anything, and even if they did, if it was viable I’d be passing down my bad Y chromosome so any future son would have infertility as well or have malformed/ambiguous genitalia.
All in all, it’s been a tough week and the only options at this point are likely a donor or adoption. Wanted to share my story in case others have no had the DNA test done, it’s very simple and has been very eye opening. Stay strong, y’all!
Here’s the specific lab note on my results for anyone curious:
RESULT:
ABNORMAL MOSAIC KARYOTYPE
INTERPRETATION:
Chromosome analysis revealed an abnormal mosaic karyotype.
One copy of the X chromosome (45,X) was observed in 8 out of 20 cells metaphase cells analyzed, and one copy of the X chromosome with isodicentric Yq chromosome (resulting in loss of Yq region) was observed in 12 out of 20 metaphase cells. Individuals with this mosaic karyotype may present phenotypes ranging from sterile but otherwise normal males to females resembling testicular feminization, to ambiguous genitalia.