Clinical trials for late stage OC
Has anyone had any experience with clinical trials for late stage ovarian cancer?
My mom (55yrs) was diagnosed with stage 3 high-grade serous ovarian cancer in May 2025, her CA125 was in the 4,000s at time of diagnosis. She underwent 4 rounds of Carbo-Taxol chemo, then cytoreduction surgery to remove ovaries, fallopian tubes, uterus, and omentum followed by HYPEC. She then did only 2 more rounds of chemo after that since her CA125 dropped so fast all the way down to 13, and her imaging showed no signs of cancer. She was declared NED in November 2025 and has been on Lynparza + Avastin for maintenance therapy.
Fast forward to March 2026 and her CA125 started a slow trend up from 13 -> 20s -> 40s (now stable at 40 for last 2 draws). She just had a PET scan last week which showed increased uptake in her right pelvic lymph node and in 2 small areas on her omentum and mesentery. Dr. believes that we are in the early stages of recurrence with really low tumor burden and slow progression for now. He suspects platinum resistance since the recurrence was very early, and mentioned that he thinks she could be a good candidate for the CATALINA-2 trial if her biopsy comes back positive with the specific protein the drug targets.
I’m curious if anyone has any successes from clinical trials for late stage ovarian cancer, or if there is any other treatment types I should ask about.
Thanks!