Membranous nephropathy diagnosed
My mom has membranous nephropathy with anti pla2r level of 54 , then doctor give 2 doses of rituximab inj each of 1 gram , first dose was given on 19 Feb 2026 and second after 14 days gap , then after one month her anti pla2r level was negative and with value of 11 , and proteinuria was 2.6 g/day now after one month her proteinuria is increased to 3.7g/day , why she has no improvement, even bp is always normal , not eat protein foods , she follow everything that doctor ask , she is taking 3 medicine dapa 10mg, sofvasc 10mg , rovista 10mg , on this 19 may almost completed 3 months for rituximab inj first doses.
My question is why proteinuria jump from 2.6g to 3.7g even anti pla2r level goes negative and also dose rituximab inj help or not till now no improvement in proteinuria.