Hi everyone, I was diagnosed with low-grade endometrioid endometrial cancer (G1). Overall, my case has been consistent: low grade, high ER/PR, slow progression.
What’s confusing me: my first IHC showed a normal (wild-type) p53 pattern, but after a more extensive resection, my second IHC came back similar for all markers except p53, which was reported as ~90% positive. However, the report didn’t describe staining intensity, didn’t define the pattern (wild-type vs overexpression, etc.), and p53 wasn’t even mentioned in the conclusion, while all other markers were clearly interpreted.
So basically, every marker followed a clear reporting pattern except p53. Because of this, I’m sending my slides for review at another lab.
Has anyone had a situation where a pathology/IHC result came back inconclusive or not fully interpreted, or where a pathologist didn’t make a call on a marker? Not necessarily p53, just wondering how common this is and what happened after a second opinion. I’ll be seeing my doctor in a few days, so I’m just trying to ease my anxiety in the meantime.
Thanks 🙏