u/No_Affect_7316

I've been on Tirz since the 3rd week of March. I always loved shot day/next day because I felt so...different. My stomach felt so full, I had more energy, I just felt...different. I could "feel" the medicine working in my body. It definitely wore off by the next shot day and then it started all over again.

I was on 2.5 mg for 6 weeks and last week, I titrated up to 3.5 mg because my weight loss had slowed so much. I've had two 3.5 mg shots now and...it feels different than earlier. I don't have that "full" feeling and all the energy. I just feel...normal. Like I didn't take anything at all. Now, I should say that I'm NOT having food noise or cravings on either dose. I just don't have that stuffed/indifferent to food feeling that I initially had. It's hard to explain. More like at first, it was, "Cake? Why would I want cake? That looks about as appetizing as dog food." And now it's: "Cake? That looks good. But I am going to stick to my plan of better nutrition and higher protein." If that makes sense. The Tirz, I don't "feel" it in my body now like in the past. Like most other people, I had a lot of loss at the beginning and now it's slowed way down.

Is it just our bodies getting used to the medication? Just curious if anyone else has experienced this...and if there's a correlation between the intensity of the "feeling" of the medicine and actual weight loss. I'll be tracking it for myself but curious what others have noticed!

Huge milestone today! I've been really inspired by all the photos of people donating too-big clothes, but I've been afraid to. I've been afraid that Tirz is too good to be true, that any day now the weight loss will stop and I'll start gaining again, just like with every other diet I've been on for 30+ years. I haven't truly trusted that I could actually DO IT this time. How many times have I lost weight, donated my plus size clothing and then ended up gaining weight and having to buy all new stuff? Too many times to count.

But, deep breath...I'm going for it. I've been on Tirz for almost 7 weeks and am down 17 lbs (down nearly 30 lbs in total since I started over in February). I haven't had a disordered eating episode since starting Tirz and have been completely free of food noise. I still have about 40 lbs to lose, but today I bagged up 3 oversize garbage bags full of stuff that was too big and even scarier, stuff that I can wear NOW but that will be too big when I get to goal. I only saved my favorites (still 4 boxes full). Yikes, this is hard! But I am going for it! :)

I’m meeting with my doctor tomorrow and wanted to get some feedback here before I go.  I’ve been on HRT (.05% estradiol with 100 mg progesterone) for about 8 months.  No problems.  I started Tirzepatide at the end of March.  My weight loss had been GREAT...about 12 lbs in 5 weeks.  I started having trouble sleeping, contacted doctor, and she upped my estrogen to .075%.  IMMEDIATELY – the very day of new patch – weight loss stopped.  Nausea, headaches, felt terrible, slow weight gain despite a tight grip on calories, for two weeks.  I decided to cut down my new patch to the old .05% dose and immediately, nausea stopped and all other symptoms went away...and my weight started creeping down again (also increased Tirz dose from 2.5 to 3.5 mg).

 I’ve done some research and looks like doctor should’ve upped my progesterone, not estrogen, for sleep issues.  But it also looks like increased progesterone can cause bloating and insulin resistance (i.e. weight gain).  The other option is to keep things the same but get a patch that has .05% estradiol and 100 mg PROGESTIN, not progesterone.  But I read that progestin can ALSO cause water retention and insulin resistance/weight gain.

 I want to protect my uterus, of course, but I also want to lose weight!  I have almost 50 lbs to lose.  Can anyone tell me their experience with increased progesterone vs progestin in patch form?  If you experienced the water retention/insulin resistance, how long did it last?

Thanks!

Ack!! I've been on HRT (.05 estradiol) + 100 mg Progesterone for about 6-8 months. Used to work well on my symptoms but lately, my sleep has been poor again. Doc upped my estradiol (patch) to .075. BOOM! Instantly...I mean the DAY I tried the new patch...weight loss stopped. I'm on week 6 of 2.5 mg Tirzepatide. Have been losing weight at a really fast clip, 2-3 lbs/week. And then...nothing. Zero loss, two weeks in a row. Plus, my peri symptoms have returned: nausea, super itchy skin, headaches. Anyone else experienced this? How long did it last?

I've been on a .05 estradiol patch + 100 mg oral Progesterone for 6-8 months. Worked great at first but the past few weeks, my sleep has gotten really poor again. I contacted my doctor and she upped my estrogen to .075 (Progesterone stayed the same). The first week I felt the same...sleep not much improved. Thought I'd wait it out and added a GABA supplement to help with sleep. Instantly, my sleep improved. Six days later, boom! Woke up with a headache...skin has been super itchy all over, especially my armpits...and low-grade, constant nausea. Two days now. These are all symptoms of pre-estradiol and definitely feel 'hormonal.'

I'm meeting with my doctor next week, but just looking for others' personal experiences. I know that side effects like nausea are normal, but I didn't have any side effects until 2 weeks later. Since the increased dosage doesn't seem to be helping (improved sleep started the night I took the GABA), maybe go back down? Increase Progesterone? Wait it out?

To muddy the waters, I'm also on a GLP-1 (Tirzepatide) that can cause nausea, although I'm 6 weeks in and haven't increased my dosage, so I'm not convinced that this is a contributor.

Anyway, yes, I will get the official word from my doctor next week...just looking for others' experiences in this department. Thanks!