▲ 0 r/Virology
Came up with a hypothesis about using an engineered self-spreading particle with a CRISPR payload to target HIV reservoirs — is this close to anything real? Looking for expert feedback
An engineered therapeutic interfering particle, mimicking HIV's cellular entry mechanism, that parasitises HIV-infected cells by outcompeting viral replication machinery, while carrying a HIV-RNA-sensitive CRISPR payload that activates exclusively in infected cells — achieving self-disseminating, reservoir-clearing, functionally curative HIV suppression from a single administration.
u/Maleficent_Tree1789 — 10 days ago