Fatigue that doesn't respond to sleep, what categories am I missing
The frustrating thing about my fatigue is that it doesn't respond to sleep. Eight hours, same. Five hours, same. Nap, same. The tiredness is consistent in a way that makes me think it's not sleep-related at all.
Standard stuff I've ruled out or addressed: thyroid normal, iron normal, B12 normal, vitamin D supplemented, sleep apnea tested negative. I exercise regularly which usually helps but has stopped making a significant difference.
Starting to think this is something cellular or mitochondrial. Read a bit about AMPK signaling and mitochondrial function and it resonated more than the usual fatigue explanations. But I don't have a clear next step.
What categories of fatigue explanation do people find useful that don't show up in the standard workup?