Beat Biome 1 on my 3rd try. Took 2 more tries to beat Biome 2. And from there, I proceeded to first-try biomes 3 and 4 without dying. Have I potentially missed out on significant lore or important exposition?
I had really fortunate godlike luck pouring out of me during that 5th run (or 6th if you count the starting tutorial run). Found an artifact early on that made it so I only needed 2 Resins to upgrade Integrity. And it was RAINING Resins. Between an ungodly amount of integrity upgrades, and sprinkling a healthy amount of protection upgrades on top, I basically turned Selene into a tank. Nothing could kill me, even when I made a bunch of stupid mistakes.
And just now I somehow managed to scrape by, make it to this Biome 4's boss, and down it on my first-try with a SLIVER of health remaining. So now it's onto Biome 5 😅