I've been doing this 25 years and I keep noticing patterns that no class teaches you, you just get tired of seeing them.
Mine right now, every CAPA I've seen close out and then re-open within 18 months had the same root cause label as some other CAPA from the same area in the prior 24 months, and nobody linked them at the time. The label was right, the containment was different, but the fix was always one layer above where the label pointed. I started running a quick scan for repeat labels before signing off, and our re-opens went from maybe 4 a year to 1.
What's yours, the failure mode you only spotted after a decade of watching it happen?