u/Kooky_Jelly_5612

I have suffered from depression and anxiety for over 30 years. During that time I’ve probably tried in excess of 15 antidepressants to no avail. Most were SSRIs but there have been others such as wellbutrin, mirtaziapine and several antipsychotic meds. Nothing has worked. I recently discovered that I’m COMT met/met and now have a better understanding of what might work. I’m contemplating asking my doctor for Pristiq. Has anyone had success with this med?

I was diagnosed with hemochromatosis about five years ago (heterozygous for C282Y and H63D). I typically have phlebotomies every six months and try to keep my ferritin levels under 100. During that six month period my ferritin levels slowly rise and sometimes reach 140 before I undergo another phlebotomy. During the past 8 months my ferritin levels, for some inexplicable reason, have been falling. I haven’t had a phlebotomy in eight months and my ferritin level is currently at 67. One month ago it was 78, so it seems I’m dropping 10 points a month. No indication I have internal bleeding. I’m male and 66 years old. Any suggestions why my ferritin is suddenly dropping?