Parnate Introduction Period Side Effects
Hi all,
I started parnate May 2nd for melacholinic depression with severe anhedonia induced by bpc-157. PET imaging shows moderate hypo-metabolism of the bilateral medial temporal lobe with hippocampal volume loss. Claude Opus 4.7 model believes my the reward pathway is under active at the hippocampus level projecting into the VTA due to the scan and the fact that ketamine helps me some (it disinhibits the VTA). Pre frontal and basal ganglia are functioning normally. But unfortunately ketamine doesn’t last and only has partial response.
First few days on parnate I felt optimism but days later it turned into sedation, dead dick, and general apathy and fatigue. It feels like a SSRI to me and this happened early on Nardil which is why I switched to parnate. I raise the dose and I feel a little better when I first take the dose but later turns back in the sedated feel. I am at 15mg now and will discuss with my doctor today raising the dose.
Does anyone know about this type of response? I want to push through to the therapeutic dose but I am getting worried I will just have a serotonin dominant response to MAO and just get worse.
Any comments appreciated