u/JadCerv

Have you noticed a change in the quality? I've been on it since February and was doing quite well after switching over from patches and gels. I'm on estrace 2 mgs. I just refilled my prescription last week, and it's like I'm taking a placebo. In just 2 days, I crashed. All my symptoms are back with a vengeance, including the night sweats, which I've not had since starting HRT in the fall of 2024.

I'm wondering if there's something wrong with the pill. I find it hard to believe that I went from doing so well to crashing just days after starting the refill bottle. I've seen some posts about defective estrogen patches in some subreddits and other places on social. I'm wondering if the quality assurance issue has now hit the pills.

Anyone else noticing this problem? I have a call into my pharmacist about it, but thought I'd ask here as well. TIA!

I have dealt with systemic inflammation issues for about 5 years. A rheumatologist tested me for every autoimmune condition there was a test for. All came back negative. I started HRT 16 months ago and that helped some, but I still have awful flareups from time to time.

I follow an anti-inflammatory diet but that only helps so much.

I saw an article about GLP-1s and some newer research suggesting they may help with chronic inflammation. Has anyone been prescribed GLP-1s for this reason? If so, do you think they helped?