u/InternationalOil9733

Lost 55lbs in 6 months on Retatrutide and it is hands down the best decision I have ever made.

I started Retatrutide six months ago, and even though some weeks felt like a total waste, I stayed on top of my water intake and pushed my protein levels. Today I am officially 55 pounds lighter, which is the most weight I have ever lost in my life, and I feel like a totally different human being. All that constant inflammation is gone and my energy is just higher than I ever thought was actually possible. This is not a miracle shot, it is just about being consistent and letting the drug do its work. Reta is miles ahead of any other weight loss plan I have ever attempted. If you are stuck wondering if you should try it, just do it. Stay on top of your work and stay consistent while using it. This stuff will not let you down.

reddit.com
u/InternationalOil9733 — 2 days ago

Online risk calculator for GLP-1 associated pancreatitis

A research group developed a risk calculator based on FDA adverse event reporting system data. It estimates individual risk of acute pancreatitis based on:

  • Age

  • Sex

  • History of gallstones

  • History of pancreatitis

  • Alcohol use

  • Triglyceride levels

  • Which GLP-1 (different drugs have different reported rates)

I put in my numbers (46M, no gallstones, no prior pancreatitis, rare alcohol, triglycerides normal). My estimated 1-year risk was 0.07%. That's 1 in 1,400. For comparison, the risk of acute pancreatitis in the general population is about 0.05% (1 in 2,000). I feel better. The absolute risk is tiny, even if the relative risk is increased.

reddit.com
u/InternationalOil9733 — 6 days ago

I switched from Ozempic 2mg to Mounjaro 10mg (with a washout week). I wore a Dexcom G7 for 2 months on each drug. Same diet, same exercise.

Ozempic 2mg results:

  • Fasting glucose: 110-120 mg/dL
  • Post-meal spikes: up to 180
  • Time in range (70-140): 68%
  • Mounjaro 10mg results:
  • Fasting glucose: 85-95 mg/dL (dropped 25 points)
  • Post-meal spikes: up to 140
  • Time in range: 89%

The GIP component in Mounjaro seems to make a real difference for my fasting glucose. My endo said some people are "GIP responders" and others aren't. I guess I am.

reddit.com
u/InternationalOil9733 — 9 days ago

I have been overweight for as long as I can remember, but I finally hit my goal weight this morning just a few weeks before my 32nd birthday. For context, I am a 5'5 female, started at 240 lbs, and today I finally weighed in at exactly 145 lbs. I spent my entire twenties trying every diet and tracking app out there, but the progress was always so miserable that I would eventually just quit and gain it all back. Starting Reta completely changed things for me, and even though the last five pounds took forever to drop, it was totally worth it to finally find a tool that actually works.

Losing this much weight has completely changed how I experience life. At my heaviest, I went on a trip to Colorado with some friends and got so out of breath walking up a basic dirt trail that the entire group had to stop and wait for me, which was incredibly embarrassing. Now I actually have the stamina to go out and do things without constantly stressing about whether I will physically be able to keep up or if I will hold everyone back. I am so grateful to finally just exist in a normal body, and a huge thank you to everyone in this sub for sharing your advice and keeping me motivated whenever the scale stalled out.

reddit.com
u/InternationalOil9733 — 12 days ago

I don't have diabetes, but I've always suspected I have reactive hypoglycemia (which are blood sugar crashes after meals). I bought a 3-month supply of a popular CGM (over the counter) to test.

Findings that surprised me:

  • My fasting glucose dropped from 95-105 to 75-85 within 2 weeks of starting my supply of grey tirzepatide at 5mg.

  • I wasn't having reactive hypoglycemia. I was having reactive... nothing. My glucose would spike to 160 after a carb-heavy meal and then slowly drift down over 4-5 hours. No crash.

  • The biggest change wasn't the peaks — it was the valleys. My glucose stays in a narrow range (70-120) almost all day now. No roller coaster.

  • On days I don't eat enough, my glucose drops into the 60s at night. Not low enough to be dangerous, but low enough to wake me up.

reddit.com
u/InternationalOil9733 — 14 days ago

Over 13,000 patients with type 2 diabetes and heart disease were followed for nearly 4 years. The results are worth paying attention to:

All-cause mortality: 16% lower with tirzepatide vs dulaglutide (8.6% vs 10.2%, HR 0.84)

Composite renal endpoint: 21% lower (4.9% vs 6.1%, HR 0.79)

Coronary revascularization: 16% lower (8.0% vs 9.4%, HR 0.84)

The lead author, Dr. Steven Nissen from Cleveland Clinic, said: "It's important to remember that this benefit was against a very good drug that had already shown cardiovascular benefits. In that context, a 16% benefit is a big deal". I started tirzepatide for weight loss. That's what I told myself. But my dad died of a heart attack at 62. Seeing all-cause mortality data like this changes how I think about being on this medication long-term. It's not about the scale. It's about showing up for my kids' graduations.

https://consultqd.clevelandclinic.org/dual-agonist-incretin-therapy-outshines-glp-1-agonist

u/InternationalOil9733 — 17 days ago