A1C / glucose progress after 3 months on tirzepatide
For reference:
- I began tirzepatide on February 2, 2026.
- I followed a mostly standard titration schedule and am currently on 7.5 mg.
- I have lost 38 pounds in 13 weeks (a pace of 2.9 lb per week, which is considered healthy for my starting weight).
Here is the change in my A1C and glucose levels in those three months....
January 2026
A1C: 6.3%
Estimated glucose: 134
Fasting glucose: 124
May 2026
A1C: 5.1%
Estimated glucose: 100
Fasting glucose: 101
I'm sure most people on this forum recognize 6.3% to be dang near the highest possible prediabetes number. One point more and I would have been diabetic. Today, I'm well below the "normal" A1C line of 5.7%. It's truly stunning.
In case anyone is interested, cholesterol and liver function improved dramatically as well.
Total Cholesterol: 222 → 195
LDL: 142 → 127
Triglycerides: 176 → 143
AST: 42 → 29
ALT: 58 → 40
The only "concerning" numbers, which aren't that concerning, were:
HDL dropped slightly (within 1 point of normal)
eGFR dropped slightly (still in normal range)
Potassium dropped slightly (lowest normal value, but still a drop)
I'm not surprised by the potassium drop. Tracking my macros has revealed that I just do not seem to ever hit my potassium goal for the day.
This, not the weight loss, but THIS, is why to me it is a miracle drug. It's stunning to me.