u/Flaky_Amphibian_5597

My hair started shedding the day of my 2nd Enhertu. It’s at least all over my head equally but if it keeps up at this level, I will be bald by Enhertu no. 3.

What are people’s experiences with the great shed and regrowth?

I’ve not had significant nausea, fatigue or any toilet issues so far, this is the most distressing side effect and only because hair is everywhere. I’m going the shave tomorrow but am hoping the shed calms the f&$k down!

I just wanted to share my experience with my first Enhertu infusion so there’s different experiences being shared (feel free to add your own).

I was very nervous going into Enhertu as I have an imbedded fear of nausea from motion sickness as a child and all the other things that come with IV chemo.

I have Bipolar Disorder 1 so do not get steroids, just Zofran prior and then another med days 1-6.

First infusion was long, but had the most amazing nurse who was so calm and methodical. Felt great afterwards (meds plus the glucose drip). I took 5mg of the additional med and woke up partly sedated so we cut the dosage.
Days 1-6 really very low lingering nausea that went away once I got up and moved and ate.

I have most of my mets in my bones and bone marrow and had very low platelets and red cells going into treatment. My red cells crashed so I felt sick days 12-15 because of that and had to have a blood transfusion. If not for that I would have felt fine, I had no break through nausea days 7 onwards.

I was able to do Pilates and work with the anaemia my only challenge.

I had a review yesterday - my platelets have doubled since infusion and my white cells have held steady!

I’ll be continuing at 80% due to my bone marrow mets.

Other side effects;
Dry skin
Running nose
I got a weird skin rash of a few cyst like pimples that are apparently related to the targeted therapy - uncool.
Constipation days 7-8
I think I might be shedding slightly more - really a few hairs more and it maybe due to the anaemia plus chemo.
Hard to tell re fatigue due to anaemia.

One thing - I have a few chin hairs that I battle with often daily and they haven’t come back. All other hair still in place.

So way better than AC chemo. I might get slammed on my second and third rounds but this is tolerable.