u/Famous_Difference_45

Our daughter is 18 months old and was diagnosed with DMG with an EGFR mutation.

We are trying to understand whether targeting EGFR in combination with ONC201 could help restore or improve its effectiveness (as EGFR may contribute to resistance to ONC201).

Does anyone have experience using EGFR inhibitors together with ONC201? Which EGFR inhibitors have been used?

We are also wondering whether ONC206 shows similar resistance mechanisms related to EGFR, or if it may behave differently in this context.

If anyone is able or willing to share insights on this, it would mean a great deal to us. Thank you very much in advance.