I shared last week that I was experiencing anhedonia for the first time after two years of being on Zepbound. It was confusing to me because in December I went down from 7.5 every two weeks to 5 every two weeks (after maintaining on 7.5 every two weeks for a year). I was surprised at how "meh" I felt.
Over the course of the four months on 5, I started having intense cravings for sweets, developed anhedonia (for the first time), and started noticing an uptick in inflammation/joint pain. Not to mention my weight started to trend upwards. Not significantly but I could just tell by the way I felt that it wasn't working. I decided to go to every 10 days instead of every 14 days and still it just wasn't hitting the way it used to.
So this morning I went back up to 7.5 (one week after my last injection of 5) and it's like the fog cleared. I feel both more relaxed AND more engaged. It reminded me of how it felt when I first started: within 24 hours, I could feel something had changed in brain’s chemistry in an almost visceral way (more peaceful, more regulated, and more relaxed). My brain was finally free. And that's how it feels to have gone back up to 7.5 this morning.