On the map in the sea, clockwise from the West of Gea Kul, North around Scosglen, and then South to Hawezar, are the same symbols used on Charms in the Talisman. Interestingly there are no charm symbols around Nahantu or Skovos. Were these on the map before LoH?
The Talisman is a circle of 6 possible symbols, the map shows 11 symbols in a semi-circular layout. The Talisman has a Horadric seal in the centre, the centre of the semi-circle of symbols on the map would be the undiscovered area North East of Saran Caldera (Dry Steps World Boss).
Could this be a hint to a secret use for the Talisman (socket the charms with the same symbols as the map, in the same positions as the map, to trigger something)? Maybe the corresponding words on the charm sets mean something when read in the same order as the map (e.g. Phoba-Fer-Mlor)? Maybe this is somehow involved with finding a luckiest coin (which I would expect to drop while under the effect of a lethal/artillery/immunity shrine), or the cow level itself?
It's also possible this is just Horadric lore, and has nothing to do with anything.