https://pmc.ncbi.nlm.nih.gov/articles/PMC12413947/
I found this study that showed caffeine inhibited mast cell activation and prevented anaphylactic shock in mice and they also had lowered inflammation levels.
The dose of caffeine given to the mice was very low. A dose of 1mg/kg in mice was enough to cause significant effects
A dose of 1mg/mg in mice translates to 0.08 mg/kg for humans. So for a 70kg human, thats only about 6mg of caffeine. I know that converting the doses from mice to humans is still not entirely accurate due to differences in caffeine metabolism of mice. So 6mg might still be a bit low
Has anyone of you ever tried to microdose caffeine? Most people flare from caffeine but I guess thats because they never tried to microdose caffeine in very low amounts because the goal of taking caffeine is usually stimulation and alertness. I will try to experiment with this. I bought caffeine pills. I will start with 5mg per day. I will make my own tincture and take it sublingually