u/Dazzling-Bluejay-897

Daridextorant + 5HTP

Hello all,

Ive recently (over last 3 months, since stopping Amitriptyline) been suffering from insomnia, where it feels like im awake all night but I know im getting sleep as it feels like “weird” thoughts (assuming dreams)

Ive been prescribed Daridorexant (Quviviq) which ive been taking for a few weeks. Doesnt seem to be making a MASSIVE difference yet but I would say im less anxious when going to bed.

But what im wanting to know is, does anyone know whether you can take the supplement 5HTP safely alongside Daridorexant? I want the 5HTP for anxiety, depression and to support sleep but im not sure where I can find out whether its safe.

Tia

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u/Dazzling-Bluejay-897 — 3 days ago

Hello all,

I was on Sertraline 50mg for around 10 years and stupidly, I stopped cold turkey in January 2025. I had no side effects when I initially stopped.

Few months later (March 2025) I had a bit of a wobbly with my mental health as lots of things suddenly went wrong in my life. I then tried to go back on it and had the worst side effects and after 2 weeks I stopped again.

April - I developed pain in my jaw which was diagnosed as TMD and progressed into severe all over body pain but specifically back of the neck, shoulders and lower back.

I was then put on Amitriptyline 20mg in June 2025 for 8 months for muscular pain. I didnt find ot was helping for this and the GP told me to stop that. Again, cold turkey (i wasnt on the right frame of mind at this point and didnt even associate ot with being an antidepressant as thats not what i was prescribed it for)

Since I stopped the Amitriptyline, I have had literally 2-3 hours of sleep a night and it feels like im never actually asleep. Im so exhausted and the lack of sleep fuels the anxiety and pain.

So here we are May 2026 and im starting to wonder whether my problems with muscular pain and jaw pain were nothing to do with TMD and everything to do with protracted SSRI withdrawal?

They gave me Fluoxetine last week to try. I took two capsules and nearly ended up being pushed over the edge of not wanting to be here anymore so i had to stop. Since then; the anxiety has been coming in wave (didnt have that before i took fluoxetine) and i cant yawn. Feels like my nervous system is in disarray.

So. I guess what im here for is to see whether others have had a similar story and have come out the other side. Im 15 months off sertraline and 3 and a bit months off amitriptyline but this is the worst ive ever felt physically.

Has anyone tapered back on SSRI to counter the physical side effects this long after stopping?

Im in the UK and no doctor ive seen understands and they all get irritated with me because i contact them frequently in crisis and its near on impossible to gain access to a Psychiatrist.

Really hoping for some hope. I feel so mad at myself that I stopped cold turkey but at the time, i wasnt in the right frame of mind and had a lot going on, I dont even think they were “working” at that point anyway, hence i stopped them to see how i felt.

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u/Dazzling-Bluejay-897 — 14 days ago