Severe uncontrolled asthma, GINA 6
Heyho, thought I would share my story since I'm feeling very alone with this
I'm currently 19 years old and got diagnosed at 12 years old. Symptomatic since being 11 months old.
We started with Viani mite 2-0-2 and Montelukast. Didn't worked enough. We switched to Viani forte 2-0-2, Montelukast and Spiriva 2-0-0. Didn't worked either.
In October 2022 I started with Dupilumab 200mg every 2 weeks, as my IgE came back at 711 kU/l and my eosinophiles at 300. I didn't noticed an effect, so we upped the dose to 300mg every 2 week at July 2023. In August 2023, I had a severe status asthmaticus/near fatal attack with a breathing arrest (SpO2 40% and GCS 3).
Because of that we switched to Tezepelumab 210mg every 4 weeks in October 2023. My asthma got worse despite that, went to rehab 2x but nothing got better. I switched my university clinic and they took me off Tezepelumab in February 2026, as it somehow didn't work on me either, despite being THE biological.
2 days ago we started with Omalizumab 300mg. We started with a lower dose, because my IgE levels have to be checked again, but we didn't wanna wait so long. So maybe the next dose will he higher. Since the first dose I'm experiencing massive nausea and vomiting, headaches and fatigue - yes, fatigue, not just tiredness. I didn't had these side effects on the other two biologicals and I'm wondering if this is normal? I can't really eat, but I'm at a little bit too much body weight, so it's not dangerous at this point. I'm just wondering.
Does anybody have a similar story to mine? Are these side effects "normal"?