I don't understand why I'm so reactive these days. I definitely have some issues with dysbiosis (working with a practitioner to address them), and I've long had issues with stress/DPDR...but, up until today, hydroxocobalamin has typically helped that.
I used to take the Seeking Health hyrdoxo/folinic acid combo--anywhere from 1/4th to 1/2th of a tablet--and...it usually did something. I could focus better most of the time; sometimes my mood notably brightened.
I began supplementing it again last week and found that while it did result in lifted mood at first, it also provoked extreme histamine release. That's how I understood it, at least--I felt overcome with rage, hyperstimulated and overwhelmed, on day 2 of supplementation.
To see if it had anything to do with one over another (hydroxocobalamin v. folinic acid), I ordered them separately (the Seeking Health versions). Took 1/4th a tablet of hydroxocobalamin this morning and felt pretty damn out of it for a while, but then evened out by early afternoon and could focus a little better.
When I tried folinic acid, though, I took even less...like, maybe 1/6th of a tablet?...and started to feel extreeeemely spaced out and blunted relatively quickly. This lasted a few hours, and when I got home, I took some riboflavin/B2 (400mg) to see if that would help. The thinking was that maybe there was an MAOA bottleneck, and that the B2 might help clear it.
This resulted in a depressive wave that came on slowly throughout the evening and settled into a dark, gray peak by 10PM. Half of me feels like crying. The other half of me feels nothing. I'm humbled and realizing that maybe I actually don't understand this stuff at all.
I like to think that this is just a biochemical funk, and that nothing in me is irretrievably broken, but lord: I am exhausted, I am overwhelmed, and I could really use some insight. If anyone has any recommendations, I would be so, so appreciative.
N.B. I don't have pernicious anemia, but my B12 has always been borderline or outright low for years--I have some gut issues that make malabsorption a real problem.