61 YR old Man Cream TRT Treatment 13 weeks labs, how to dial in
As the title says a 61-year-old man started TRT 13 weeks ago, and attached are my before and after labs. I was clearly dehydrated when I took my second labs. I got on TRT to really try and improve my mood and Energy, along with an overall I don't want to get really old like this mindset of conditioning and health. Also on Wegovy (yeah, I know, should have done Tirz, or Reta). Starting conditions were 267 lbs 6'4, target weight was 230, but still working on figuring out the endpoint. May end up being 220. I am a very wide frame. I have been a casual gym guy for the last 20 or so years. Now I am kicking it up a bit as part of the get-in-shape program and using kettlebells daily. Along with the TRT, I also added Boron and increased Creatine to 5 and now 10 grams a day. I take protein twice a day.
I am working with Defy on the cream, and I went with cream because it was a way to ""ease"" into it, and I am doing one click morning one click evening scrotal application. The other benefit of this ""microdosing is that I wouldn't have peaks and valleys.
What have I seen as a result? Definitely improved mood and energy, was hoping for more, but it's a lot better than it was. My oily skin is back with a vengeance, and facial hair growth has increased in speed. Gym results are much improved, drive is very slightly improved, and function is about the same, unfortunately. Mood was the biggest surprise; it has definitely mellowed me out. Can this be attributed to the high estadiol?
Concerns with my labs, Hemocrit is higher than I would like, even considering dehydration. and my estradiol is high. Defy gave me pills for it, but frankly, what I can find in research is my numbers aren't bad enough to chase it with meds
The compounded cream I am on is 200mg/ml; here is the surprise to me at least. I am taking half the dose they recommended; they had recommended 2 clicks twice a day, I am doing one twice a day. So that's 2 x 25mg of Test a day 50 mg total 350 a week. However, with creams I have read that the absorption is no more than a third of the dose so this is about 120mg/week injection equivalent.
How do I dial this in? My plan is to continue to drop weight that should help with reducing T conversion, along with changing application to one scrotal and one shoulder or groin application. I am also wondering about dropping the boron, but to me it seems illogical to cut natural production, and rather I should keep that high and trim supplementation. Another strategy would be to skip every other night's application.
I am absolutely following up with the clinician at Defy, however, if I had started with their starting dose, I would have grossly overshot. But thought I would share my results, as there are some really sharp people here in the forum. As a question, let's say I was able to keep my T and free T the same but drop Estradiol 30 percent, what, if any, changes would I see?
