I started with Trestolone Acetate (MENT) at 1mg/day. Libido shot up instantly, but after a week, I noticed significant chest tightness. I added 0.2mg Estradiol Cypionate (EC), which helped slightly, but the tightness remained until I added 30mg Pregnenolone. That resolved it.
To simplify, I’m making an 'all-in-one' 10ml solution in MCT oil.
The Formula (10ml Total Volume):
2ml Trestolone Acetate (50mg/ml)
1ml Estradiol Cypionate (10mg/ml)
1ml Allopregnanolone Cypionate (100mg/ml)
~6ml MCT oil (Fill to the 10ml mark)
The Dosage:
At 0.1ml (10 units) on an insulin syringe, this provides:
1mg Trestolone Acetate
0.1mg Estradiol Cypionate
1mg Allopregnanolone Cypionate
Logic & Observations:
SHBG: Trestolone has low affinity for SHBG, so a little goes a long way. My BP remained consistent at 110/75.
DHT vs. MENT: Trestolone doesn't 5-alpha reduce, but it is a potent androgen with high AR affinity. It is more prostate-sparing than Test because it doesn't convert to DHT in the prostate, yet it's strong enough to maintain prostate health/size as shown in primate studies.
Metabolism: It 5-beta reduces in the liver, leading to effective glucuronidation and elimination.
The 'GABA' Factor: Trestolone is a strong progestin. For some, this causes a 'tight chest' or anxiety feeling (GABA-A interference). Adding Allopregnanolone (a GABA-A positive allosteric modulator) completely eliminated that side effect for me.
So far I've gained 10lbs after finishing a cut. With little increase in body fat. This is a work in progress. Just thought I'd share my experience.