50/F with genetic high cholesterol. Super active running, walking, and cardio kickboxing five days a week. I also have insulin resistance, hypothyroidism, and Hashimoto’s so I take a low dose of Zepbound every other week to regulate my insulin and blood sugar since my A1C was prediabetic no matter how strict I was with diet and exercise. I can’t tolerate statins of any kind, so I’ve been on Ezetimibe since September. Cholesterol has dropped from 241 to 204 while on it. Recently had a calcium CT, and they found I have some blockage in my right artery. So my cardiologist put me on Repatha. First shot has been pretty miserable. I’m lower back aches if I stand or sit, pain in my hips, and cramping down into my calves and feet. This is just like it started with all the statins. I also have zero appetite….as in just the thought of food or drink makes me feel sick. The Nexium I take daily isn’t touching the indigestion. I haven’t wanted to eat or drink anything at all since taking the first dose yesterday morning. I’m at a good healthy weight now with my A1C under control, so my endocrinologist doesn’t want me losing any more as I will be underweight. Is this what it’s going to be like every day now or even every two weeks I take this? I was skeptical and fearful to even try Repatha due to the side effects it can have, but my dr wants my cholesterol at 70 or lower. I don’t know if I can do this if this is what my quality of life will be like.
Edited to add that I’ve been on Zepbound since Nov 2024 without any side effects at all even at higher doses. So, I know it is not that drug.