So even if I played tons of hours of FO4, I'm still discovering stuff each and every playthrough that ruins my idea of a perfect playthrough.
For example, last one I learned that you have to get stealth perks in a certain order to maximise damage. It was already too late. (Sandman, then Cloak, then Ninja). Man what a pain to realise late in the game.
Also, long, long ago I learned that you should leave Preston in Concord and complete Nuka world before you get him. Bummer
There's another classic: Get your stats bubblehead once you maxed them.
Another painful one: Don't start automatron if you want those sweet Tier4 vendors.
To a lesser extent: Talk sarcastic to Trashcan Carla otherwise you'll never have a chance to get that discount.
So basicaly, it's stuff that you NEED to know and they're kind of hard to find out by yourself. Google won't really help with that tbh.
So here I am sharing the knowledge that I have and asking my fellow fo4 geeks if I am missing something