I did a quick search of crexont-related posts, have not found anything about this, either in this sub or online generally.
Last week, my neuro switched me from a combo of c/l, c/l er, and entacapone 6x/day to crexont 4x/day. While the longer on-time is nice,
- it's usually not as long as advertised; I've been getting 2.5-4.5 hours per dose.
2)There's no ramping down. I go from ok to falling off a cliff.
Once I'm in the off stage from one dose, it can take another hour or more for the next dose to kick in.
I realized last night that it was weakening and reducing sensation in my legs. I'd thought that this was a coincidence. I was pricing wheel chairs. Last night, after two hours of waiting for my 4 pm dose of crexont to start working, I took my previous 6 pm dose of c/l and c/l er and took a nap. I woke up at 8 pm, and realized that my legs were back up to previous strenghth and stability. The posterior tibia tendonitis in my left foot was painful again. But I was able to take a shower standing up.
I can't believe I'm the first person to encounter this side effect.