A warning: Orin, Contagion and Durge
If you've played the game a lot, you probably know of the method of cheesing Orin by having someone (typically Shadowheart or Jaheira) drop a contagion on her while she's in disguise. Effects such as Slimy Doom persist until your battle in the Bhaal temple, giving your party an advantage.
One variant, Mindfire, will also cause her to be befuddled, meaning you skip all conversation and go straight to battle - handy if you want to skip the persuasion checks that (if failed) can cost your kidnapped companion their life. You can, of course, skip the checks by sneaking into the back room and talking to her mother's corpse, but Mindfire means you don't need to do that either.
Well, all that is fine for Tav but, for the love of Bhaal, don't pick Mindfire if you are playing Durge.
I was playing Durge after a long run of Tavs and didn't even consider what Mindfiring Orin would do. But basically, got to the temple and, instead of the cutscene where she turns into Durge and does the monologue about brain juices, it went straight into a fight which also pulled in my party members. And we all know Daddy Bhaal does not like it when party members join in, so I had to reload (thankfully this was Tactician, not Honour Mode) and leave the gang upstairs and approach Orin alone.
Problem was, the two goons (spellcaster spear guy and stabby stun mask girl) also joined in. Thankfully, Orin had also received a dose of Slimy Doom so she was stunlocked and I could deal with those two before returning my attention to her. But then all her cultists joined in once she was dead, which they don't normally do when it's Durge, so I reloaded again and this time used a lot of many target arrows to get rid of them all before finishing off Orin.
TLDR; don't use mindfire on Orin unless you want to fight her and all her friends solo.