u/CWigham98

I’ve been dealing with long-term symptoms including fatigue, brain fog, and tingling in my arms and legs, and I’m currently under Professor Melvin Lobo (long COVID doctor in London) and on LDN (low-dose naltrexone), ketotifen, and guanfacine, which have helped. My dosing has been:

•	LDN: started Dec at 1.5mg → Jan 3mg → Feb 4.5mg → now increasing to 6mg

•	Ketotifen: started Dec at 2mg → increased to 4mg in Jan

•	Guanfacine: started Dec at 1mg → increased to 2mg around Feb

The idea behind these is:

•	LDN → helps regulate the immune system / reduce inflammation

•	Ketotifen → stabilises mast cells (reduces histamine/inflammatory release)

•	Guanfacine → calms the nervous system (helps with “wired” feeling and brain fog)

I’m now doing further testing for deeper inflammatory markers like TNF-alpha, IL-6, and full cytokine profiles to check for an underlying immune/inflammatory driver not seen on standard tests.

👉 If these come back clearly elevated, the plan is to consider:

•	Plasmapheresis → removing inflammatory factors from the blood

•	Targeted monoclonal antibodies (e.g. anti-TNF) → blocking specific inflammatory pathways

👉 Goal:

•	find the specific pathway driving symptoms

•	bring it back to normal

•	allow the body to recover properly

Would be interested if anyone else has had similar testing or treatments.