u/Broad_Worldliness767

I am 6 weeks into LDN: 3 weeks at 1.0 mg, and 3 weeks at 2.0 mg. I have had side effects that have mostly passed (depression/low mood, increased joint pain and stiffness, unexplained bloating/weight gain), but overall, I'm doing okay (I think). I started LDN after being hesitant to try a GLP-1, Tirzepatide to be exact.

My doctor suggested the GLP-1 for my inflammation that is stubbornly high (between 5.5-11 throughout the last year), long Covid (high spike proteins months after illness), and I am also 40 pounds overweight even with a 500 calorie deficit and keeping my steps between 8-10k/day. I was the one who brought up LDN thinking it was more steady and long-lasting due to seeing the GLP-1 working for a time, and then you're right back where you were. Now I am feeling that I don't believe weight loss is going to be part of my LDN journey and I need to get this weight off.

I am hesitant because as I've searched this group, I haven't had much luck finding others in the same boat doing both medications. I would love any advice and experiences of people who did both and if it's advised/not advised, what to watch for, etc.

Also - I am on Levothyroxine and Liothyronine for Hashimotos/hypothyroidism.

I am 5 weeks into LDN and 6 weeks into AIP (Autoimmune Protocol). I take 2mg at night before bed (started first 3 weeks with 1 mg). I was really feeling pretty great. Inflammation was disappearing judging by about a 12 pound weight loss, and pain decreased to almost nothing. Then this week, all I have done is retain water daily. I can't be gaining actual weight as my eating has not changed at all. I'm very careful in that category. My sleep is the same, and I still get around 7000 steps a day, sometimes up to 10k. I visibly look that I am gaining weight and puffiness, feel blah and like before, and my hip joints have stiffness and pain now that I have never had before.

This is discouraging. I hate that I was feeling good and have lost that with all of this work and focus. I have read many documents that have been provided to many posters and still feel lost. Not that anyone has a crystal ball, but is this going to pass? I can't eat any more restrictively than AIP.