Importance of potassium while on folate and b12
Can't stress this enough. Supplementing with folate and b12 does use up a lot potassium. That's why in natural foods such nutrients are always combined with potassium. When someone eats a low potassium diet, high salt, high calcium, low magnesium then this would lead to big problems. Folate and b12 in natural foods are never so high like in supplements, so when taking high doses folate and b12 one needs to up potassium intake. And i mean by upping that one will probably need huge amounts of potassium to balance things out.
I've just discovered this topic because since supplementing folinic acid with hydroxo b12 i've encountered blood sugar problems and i know from the past if potassium is low then i'll get blood sugar crashes. Combined with 2-3 days high salt intake (sodium is a potassium antagonist), low potassium and on top supplementing D3 which increases calcium uptake this lead to my actual problems!
Low potassium leads to salt and carb intolerance. Probably many don't actually overmethylate but run low in potassium. The pattern is often the same: One starts supplementing folate+b12 and initially feels good (potassium levels are adequate) but over time potassium runs low because creating new blood cells consumes a lot potassium resulting in fatigue, exercise intolerance, racing heart, heavy feeling, anxiety, blood sugar crashes etc.