When spotting rearrangements during retrosynthesis, do you spam "reverse arrows" and see if the forwards arrows look reasonable? (see below)
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u/AsideRound8210 — 3 hours ago
u/AsideRound8210
I have looked through various text books, and the references given in the pasted passage, and can't find anything. When I draw out the reactive conformations, the cis always seems kinetically disfavoured due to the 1,3-diaxial clash.
Otherwise, my best guess is that the cis conformation is kinetically favoured due to less clash of the enolate protons I have explicity drawn, and other substituents of the decalin (pasted below)
u/AsideRound8210 — 11 days ago