medication not helping
A close friend was diagnosed with PD about 6 years ago, when he was almost 50.
For the past 1.5 years or so he's been taking Sifrol (Pramipexole), increasing the dose every now and again. He never felt this medication makes things any better. Even more so: he says that after every increase in the dose he feels noticeably worse, and it does not improve afterwards.
One time he tried reducing the dose, and he felt worse, so he quickly returned to the higher dose he was at.
And some times the situation got worse without any change in the dose.
His neurologist only recommended increasing the dose further.
Based on this description, can it be that this medication is good for him, even though for a long time he only feels it makes matters worse? Is it possible he'll be better off without it, even though he tried reducing the dose for a short while and felt worse?