u/Accomplished_Nose_14

Hi everyone,
I’m posting an update on my close friend Akın (39M). He was diagnosed with IDH-wildtype Glioblastoma (WHO Grade 4) located in the right thalamus and basal ganglia. Due to the deep location, surgery wasn't an option, so he only had a stereotactic biopsy.
Molecular markers:
• CDKN2A/B homozygous deletion (+)
• TERT promoter mutation (+)
• EGFR amplification (+)
• MGMT Promoter: Unmethylated
Current Status:
He is currently on the standard Stupp Protocol. Today he completed:
• 18/30 sessions of Radiotherapy (Lineer Accelerator/Tomotherapy).
• 18th dose of Chemotherapy (140mg Temodal daily).
The best part is that he is currently showing zero major side effects. His motor skills are 5/5, and he feels like a "normal" healthy person in his daily life. His spirits are high!
The only minor issue we’ve encountered is constipation for the last 5 days (likely from the TMZ/anti-emetics). His doctor just started him on a syrup/laxative to manage it.
We know MGMT unmethylated cases can be challenging, but seeing him handle the treatment this well at day 18 gives us a lot of hope. Has anyone else had a similar "side-effect free" experience midway through the first phase?
Wishing strength to everyone on this journey.

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