When I was younger, I turned the gain all the way up and ran an OD pedal out front. When I was a young man, I became more rational and kept the gain at 2 O'clock or so, mainly playing rock and metal.
These days I play clean, edge of breakup, and occasionally mild overdrive.
People say gain hides mistakes, but I actually find the opposite to be true. Proper muting and feedback become a big issue, in addition to noise. While practicing I find the high gain sound very grating on my ear. I think it's much easier to play with less gain.
I'd much rather use a compressor with mild settings.
Anyone else notice the same?