Here’s a quick update on my treatment timeline and experience with Entyvio so far. Posts like these were super helpful to read when I first started biologics, so I wanted to provide an update for anyone who might benefit from info/details. Please ask any questions you have!
I started Entyvio in July 2025. Prior to that, I had not ever reached full remission. I had maintained manageable symptoms and mild/moderate inflammation on mesalamine (pills and enemas) and prednisone whenever symptoms worsened for a decade. In Spring 2025, I flared. My calprotectin exceeded 450 mcg/g and I had active symptoms such as urgency, blood in stool, diarrhea, fatigue, pain/cramping, etc. I started Entyvio in July 2025. I had a colonoscopy in August 2025 showing active inflammation. By late September 2025 I felt noticeably better but still had urgency and diarrhea.
Unfortunately, in November 2025, I got surgery to correct a deviated septum and was on preventative antibiotics. Whether it was the antibiotics or the stress on my body from the surgery and recovery (or both), I am unsure, but I SPIRALED into a very bad flare. My calprotectin exceeded 2,500 mcg/g. I was having upwards of 15-20 bowel movements a day, many of which were only blood and mucus. I was put on a 30-day course of prednisone and my Entyvio schedule was adjusted for an infusion every 4 weeks instead of every 8 weeks. I received the first short-interval Entyvio dose on NYE 2025.
Since January 2026, I have seen gradual and steady improvement. In March 2026, I began regularly taking famotidine (Pepcid) to combat heartburn. Since mid March, my symptoms have vanished. I have a max of 2-3 bowel movements a day. They are fully formed and pain-free with zero blood or mucus. I have more energy than usual. In late April 2026, my calprotectin was back within the normal range. I’m significantly less bloated than usual and have lost about 10 pounds compared to December 2025. I’m sleeping better and have energy to exercise.
It has been a rollercoaster. I see my GI doctor next month and we will then schedule a colonoscopy to hopefully confirm clinical remission. I genuinely never thought I would feel this normal again after 10 years of managing symptoms. I do feel like I’m on borrowed health or something, just waiting for the other shoe to drop to go back to feeling crummy. But I’m going to enjoy my health while I have it.
Other relevant details - I’m 26f, diagnosed at 16, live in the US. I have very good health insurance as I work for local government. My GI doctor is at a specialty clinic for a university research hospital in the Midwest. I still take mesalamine pills daily and actively get Entyvio infusions every 4 week.